Brian C Cooley Selected Research

Hemophilia A (Haemophilia)

3/2012	Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia.
10/2010	Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A.
7/2006	Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies.

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Brian C Cooley Research Topics

Disease

28	Thrombosis (Thrombus) 05/2022 - 01/2007
10	Venous Thrombosis (Deep-Vein Thrombosis) 01/2022 - 09/2005
7	Hemorrhage 05/2022 - 06/2003
4	Inflammation (Inflammations) 10/2020 - 12/2012
3	Neoplasms (Cancer) 01/2021 - 09/2005
3	Pathologic Constriction (Stenosis) 11/2020 - 07/2004
3	Wounds and Injuries (Trauma) 09/2016 - 09/2005
3	Hemophilia A (Haemophilia) 03/2012 - 07/2006
2	Disseminated Intravascular Coagulation 05/2022 - 06/2015
2	Hyperplasia 08/2021 - 03/2004
2	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2019
2	Vascular System Injuries 03/2013 - 04/2011
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2021
1	Reperfusion Injury 10/2020
1	Lung Neoplasms (Lung Cancer) 01/2020
1	Venous Thromboembolism 01/2020
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Hemophilia B (Haemophilia B) 01/2018
1	Thrombocytopenia (Thrombopenia) 08/2017
1	Fibrosis (Cirrhosis) 09/2016
1	Ischemia 09/2016

Drug/Important Bio-Agent (IBA)

14	FibrinIBA 05/2022 - 03/2004
8	Thrombin FDA Link 01/2022 - 03/2004
7	AnticoagulantsIBA 05/2022 - 10/2007
6	Heparin (Liquaemin)FDA LinkGeneric 03/2020 - 01/2005
5	Hemostatics (Antihemorrhagics)IBA 12/2020 - 06/2003
4	ferric chlorideIBA 12/2020 - 08/2013
4	CollagenIBA 01/2017 - 01/2013
3	Fibrinogen (Factor I)FDA Link 05/2022 - 03/2004
3	Clopidogrel (Plavix)FDA Link 01/2022 - 01/2013
3	Factor XIII (Coagulation Factor XIII)IBA 12/2021 - 01/2018
3	lipoprotein-associated coagulation inhibitor (TFPI)IBA 06/2015 - 04/2011
3	AntibodiesIBA 09/2013 - 07/2006
2	Pharmaceutical PreparationsIBA 05/2022 - 01/2007
2	Factor XII (Hageman Factor)IBA 12/2020 - 09/2016
2	Histones (Histone)IBA 11/2020 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 11/2020 - 10/2007
2	Mitogen-Activated Protein Kinase 7IBA 11/2018 - 01/2017
2	PolyphosphatesIBA 04/2016 - 12/2012
2	IntegrinsIBA 01/2016 - 03/2013
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 09/2013 - 09/2013
2	Factor VIII (Coagulation Factor VIII)IBA 03/2012 - 07/2006
1	Dacarbazine (DIC)FDA LinkGeneric 05/2022
1	LipopolysaccharidesIBA 05/2022
1	polyethylene glycol polyethyleneimine nanogelIBA 05/2022
1	GTP-Binding Proteins (G-Protein)IBA 01/2022
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 01/2022
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022
1	ibrutinibIBA 01/2022
1	AntioxidantsIBA 08/2021
1	Elastomers (Elastomer)IBA 08/2021
1	ethyl 2- (5- (4- chlorophenyl)pentyl)oxiran- 2- carboxylate (POCA)IBA 08/2021
1	Polytetrafluoroethylene (Teflon)FDA Link 08/2021
1	Citric Acid (Citrate)FDA LinkGeneric 08/2021
1	Plasminogen Activator Inhibitor 1IBA 01/2021
1	EnzymesIBA 01/2021
1	Fibrinolysin FDA Link 01/2021
1	ImmunosorbentsIBA 01/2021
1	Plasminogen Activators (Plasminogen Activator)IBA 01/2021
1	Small Interfering RNA (siRNA)IBA 12/2020
1	Biological ProductsIBA 10/2020
1	A73025IBA 10/2020
1	Heparitin Sulfate (Heparan Sulfate)IBA 10/2020
1	OligosaccharidesIBA 10/2020
1	Deoxyribonuclease I (Nickase)IBA 01/2020
1	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	Cell-Free Nucleic AcidsIBA 01/2020
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2020
1	Histone Deacetylase InhibitorsIBA 01/2019
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2019
1	ChromatinIBA 01/2019
1	Apolipoproteins E (ApoE)IBA 11/2018
1	Factor IXa (Coagulation Factor IXa)IBA 01/2018
1	Protein SIBA 01/2018
1	Clodronic Acid (Clodronate)IBA 08/2017
1	Liposomes (Liposome)IBA 08/2017
1	src-Family KinasesIBA 01/2017
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2017
1	Superoxides (Superoxide)IBA 01/2017
1	Protein Kinases (Protein Kinase)IBA 01/2017
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2017
1	AnionsIBA 01/2017
1	ApolipoproteinsIBA 01/2017
1	MMI-0100IBA 09/2016
1	MAP-kinase-activated kinase 2IBA 09/2016
1	Peptides (Polypeptides)IBA 09/2016
1	CytokinesIBA 09/2016
1	p38 Mitogen-Activated Protein KinasesIBA 09/2016
1	Factor XIa (Coagulation Factor XIa)IBA 04/2016
1	Factor XIIa (Coagulation Factor XIIa)IBA 04/2016
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2016
1	AntithrombinsIBA 06/2015
1	estropipate (Ogen)FDA LinkGeneric 06/2015

Therapy/Procedure

5	Ligation 12/2021 - 08/2013
4	Therapeutics 01/2022 - 07/2004
2	Punctures 01/2018 - 05/2015
1	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/2020
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2017
1	Intraperitoneal Injections 09/2016